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SCIENCE

 

Some of the most serious medical conditions that we suffer from are due to problems that occur somewhere in the process of cell division. As we know stem cells are the undifferentiated cells that we all have inside us. These cells all came from the zygote with constant division. All of our cells were once stem cells that got activated and so specific genes became active for the cells to develop. The medical community came to the conclusion that we can treat diseases in which cells die, such as Leukemia and lymphomas, but also Alzheimer’s and Parkinson’s disease, by implanting stem cells in order to replace the organism’s dead and diseased cells.

Perhaps the most important potential application of human stem cells is to be used for cell-based therapies. Today, donated organs and tissues are often used to replace ailing or destroyed tissue, but the need for transplantable tissues and organs far outweighs the available supply. Stem cells, directed to differentiate into specific cell types, offer the possibility of a renewable source of replacement cells and tissues to treat diseases including spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis. Although there has been some disappointment in many fields’ doctors believe that there is hope for one disease: Alzheimer’s.
Alzheimer’s Disease (AD) is one of the devastating illnesses that the human race has to face. It literally destroys the brain, as it shrinks over time due to the disease. Stem cells are being used to regenerate or regrow diseased parts of the brain. The problem with this approach is that the architecture of the brain plays an important role in the  memory process, so even if we could grow a fresh, young part of the brain to replace one ravaged by AD, there would be no memories there. Another concept is using stem cells as drug delivery agents. For example, instead of giving Crenezumab or some other drug systemically, it is possible that stem cells could directly deliver the drug within the brain from cell-to-cell, which would also be a far more effective method.

Stem Cell Research: Alzheimer's
Neuroblastoma
Although cancer is more common in older people there is a particular type of cancer called “neuroblastoma” that is evident and most common in infancy and in childhood.
Neuroblastoma is “an embryonic tumor of the autonomic nervous system” as it was described by Dr. M. Maris. It is a very dangerous type of cancer since if it is not treated, it can then spread within two to three months and kill the patient. However, with the use of standard treatment, which involves radiotherapy, chemotherapy and surgery, around 60% of the patients are treated and saved every year as Dr. Juliet Gray reports.
A new treatment which has been lately combined with the standard treatment for neuroblastoma is the ‘immune treatment’. This treatment boosts the patient’s immune system through the right combination of antibodies, and as the Professor Martin Glennie (University of Southampton) reports “immune therapy has increased the survival rates of the patients up to 20%”.
Problems that arise with the immune treatment are primarily the danger of over stimulating the patient’s immune system, leading it to attack not only the cancerous, cells but also the healthy ones. Secondly, another problem that has arisen with this treatment is that it has been proved to work only for the 3-10% of the patients. However, because on that small percentage the effect and the improvement of the patient is great, researchers are still encouraged and hopeful they will find something to benefit the wider population.
To support this idea of the major benefit the immune treatment has on individual patients, CBS news has reported the case of a 6 year old girl who was diagnosed with the most aggressive form of neuroblastoma. Having a tumor in her belly suppressing her liver and pancreas she had no other choice but to follow the standard together with the immune treatment. She was at the time in the care of Dr. Gupta (in the children’s hospital of Philadelphia), who reported in the end of the treatment that her tumor had completely disappeared and because of the immune treatment might never return. H.C. returned after the successful treatment to 1st grade and has made amazing progress since then.
Useful links for more information:
http://www.cncfhope.org/ 
http://en.wikipedia.org/wiki/Neuroblastoma#Treatments
http://www.youtube.com/watch?v=0D_1urksPS4

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